3T3 CELL-SURFACE GALACTOSYLTRANSFERASE IS A CALCIUM-DEPENDENT ADHESION MOLECULE FOR COLLAGEN TYPE-IV

被引：11

作者：

BABIARZ, B

CULLEN, E

机构：

[1] Department of Biological Sciences, Rutgers University, Piscataway

来源：

EXPERIMENTAL CELL RESEARCH | 1992年 / 203卷 / 01期

关键词：

D O I：

10.1016/0014-4827(92)90065-G

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cell surface galactosyltransferase (GalTase) has been previously shown to mediate cell spreading or migration on laminin matrices. This work demonstrates that 3T3 cell surface GalTase also mediates cell attachment to collagen type IV. Attachment to collagen type IV was blocked by perturbations of GalTase or substrate pregalactosylation on cells possessing only calcium-dependent mechanisms of adhesion. Cells with both calcium-dependent and calcium-independent systems were not affected by GalTase perturbation. Collagen type IV was shown to possess GalTase substrates since matrices could be galactosylated by both soluble enzyme and 3T3 cells. © 1992.

引用

页码：276 / 279

页数：4

共 17 条

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