HLA-DR/DQ GENE VARIATION IN NONGOITROUS AUTOIMMUNE-THYROIDITIS AT THE SEROLOGICAL AND MOLECULAR-LEVEL

被引:22
作者
BOGNER, U
BADENHOOP, K
PETERS, H
SCHMIEG, D
MAYR, WR
USADEL, KH
SCHLEUSENER, H
机构
[1] Endocrine Department of the Medical Clinic, Klinikum Steglitz, Berlin
[2] Department of Endocrinology, Center of Internal Medicine, University Hospital, Frankfurt
[3] Institute of Transfusion Medicine, Technical University, Aachen
关键词
HLA-DR/DQ; NONGOITROUS AUTOIMMUNE THYROIDITIS; PRIMARY MYXEDEMA;
D O I
10.3109/08916939209083135
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The etiology of autoimmune diseases is multifactorial with genetic factors being an important prerequisite. There are two clinical manifestations of autoimmune thyroiditis: the goitrous form (Hashimoto's thyroiditis) and the atrophic variant, which is characterized by hypothyroidism (primary myxoedema). Different genetic markers were assumed to be predisposing factors for the distinct clinical presentation. In the present study, we determined HLA A,B,C,DR,DQ alloantigens serologically and HLA-DQ by gene analysis in patients with nongoitrous autoimmune thyroiditis and randomly chosen controls. To verify the exact classifications, thyroid volume (median 5.85 ml) was measured by ultrasonography. HLA-DR5 was found in 16 of 36 (44%) patients with nongoitrous autoimmune thyroiditis and in only 26 of 175 controls (15%) (Pc=0.0018). There was a tendency towards a lower frequency of HLA-DR7 with 6% positivity in patients vs. 29% in controls (Pc=0.052). Regarding HLA-DQ, DQ7 was found in 17 of 35 patients (48%) vs. 21 of 98 controls (21%) (Pc=0.028) (relative risk 3.5). No other association was found with HLA-A,B,C and HLA-DR and -DQ. Our data indicate that the genetic susceptibility to autoimmune nongoitrous thyroiditis is closely associated to HLA-DR5 and DQ7 and not distinct from goitrous disease. We conclude that factors other than genetic ones explain the different immunological and clinical manifestation of chronic lymphocytic thyroiditis.
引用
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页码:155 / 158
页数:4
相关论文
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