T-CELL RECEPTOR DELTA-GENE MUTANT MICE - INDEPENDENT GENERATION OF ALPHA-BETA T-CELLS AND PROGRAMMED REARRANGEMENTS OF GAMMA-DELTA TCR GENES

被引:482
作者
ITOHARA, S
MOMBAERTS, P
LAFAILLE, J
IACOMINI, J
NELSON, A
CLARKE, AR
HOOPER, ML
FARR, A
TONEGAWA, S
机构
[1] MIT,CTR CANC RES,HOWARD HUGHES MED INST,CAMBRIDGE,MA 02139
[2] MIT,DEPT BIOL,CAMBRIDGE,MA 02139
[3] UNIV WASHINGTON,DEPT BIOL STRUCT,SEATTLE,WA 98195
[4] UNIV EDINBURGH,AGR & FOOD RES COUNCIL,CTR GENOME RES,CANC RES CAMPAIGN LABS,EDINBURGH EH8 9AG,MIDLOTHIAN,SCOTLAND
基金
美国国家卫生研究院;
关键词
D O I
10.1016/0092-8674(93)90112-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
T cells bearing T cell receptor (TCR) gamma and delta chain heterodimers are first generated early in ontogeny. They form distinct subsets that differ in their TCR repertoires and tissue distribution. Disruption of the mouse TCR Cdelta gene segment by a gene targeting method caused the complete loss of T cells bearing TCR gammadelta chains, but had little or no effect on the development of T cells bearing TCR alphabeta chains. The analyses of TCR gamma and delta genes in the mutant mice suggest that intracellular mechanisms acting at the level of DNA rearrangement play key roles in the differential gamma and delta gene rearrangements and in the generation of the highly restricted junctional sequences during fetal thymic development.
引用
收藏
页码:337 / 348
页数:12
相关论文
共 51 条
[1]   THE IMMUNOBIOLOGY OF T-CELLS WITH INVARIANT GAMMA-DELTA ANTIGEN RECEPTORS [J].
ALLISON, JP ;
HAVRAN, WL .
ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 :679-705
[2]  
[Anonymous], 1987, TERATOCARCINOMA EMBR
[3]   LIMITED DIVERSITY OF GAMMA-DELTA-ANTIGEN RECEPTOR GENES OF THY-1+ DENDRITIC EPIDERMAL-CELLS [J].
ASARNOW, DM ;
KUZIEL, WA ;
BONYHADI, M ;
TIGELAAR, RE ;
TUCKER, PW ;
ALLISON, JP .
CELL, 1988, 55 (05) :837-847
[4]   GENETICS OF TERATOCARCINOMA TRANSPLANTATION - TUMOR FORMATION IN ALLOGENEIC HOSTS BY THE EMBRYONAL CARCINOMA CELL LINES-F9 AND CELL LINES-PCC3 [J].
AVNER, PR ;
DOVE, WF ;
DUBOIS, P ;
GAILLARD, JA ;
GUENET, JL ;
JACOB, F ;
JAKOB, H ;
SHEDLOVSKY, A .
IMMUNOGENETICS, 1978, 7 (02) :103-115
[5]   TRANSGENIC MICE DEMONSTRATE THAT EPITHELIAL HOMING OF GAMMA-DELTA-T-CELLS IS DETERMINED BY CELL LINEAGES INDEPENDENT OF T-CELL RECEPTOR SPECIFICITY [J].
BONNEVILLE, M ;
ITOHARA, S ;
KRECKO, EG ;
MOMBAERTS, P ;
ISHIDA, I ;
KATSUKI, M ;
BERNS, A ;
FARR, AG ;
JANEWAY, CA ;
TONEGAWA, S .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) :1015-1026
[6]   BLOCKAGE OF ALPHA-BETA T-CELL DEVELOPMENT BY TCR GAMMA-DELTA TRANSGENES [J].
BONNEVILLE, M ;
ISHIDA, I ;
MOMBAERTS, P ;
KATSUKI, M ;
VERBEEK, S ;
BERNS, A ;
TONEGAWA, S .
NATURE, 1989, 342 (6252) :931-934
[7]   SIMULTANEOUS IMMUNOENZYME DOUBLE LABELING USING 2 DIFFERENT ENZYMES LINKED DIRECTLY TO MONOCLONAL-ANTIBODIES OR WITH BIOTIN AVIDIN [J].
BOORSMA, DM ;
VANBOMMEL, J ;
VANDERRAAIJHELMER, EMH .
JOURNAL OF MICROSCOPY-OXFORD, 1986, 143 :197-203
[8]   ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].
CAPECCHI, MR .
SCIENCE, 1989, 244 (4910) :1288-1292
[9]   T-CELL RECEPTOR DELTA-GENE REARRANGEMENTS IN EARLY THYMOCYTES [J].
CHIEN, YH ;
IWASHIMA, M ;
WETTSTEIN, DA ;
KAPLAN, KB ;
ELLIOTT, JF ;
BORN, W ;
DAVIS, MM .
NATURE, 1987, 330 (6150) :722-727
[10]  
ELLIOTT JF, 1988, NATURE, V331, P627