SALT-DEPENDENT PREMELTING BASE-PAIR OPENING PROBABILITIES OF B-DNA AND Z-DNA POLY [D(G-C)] AND SIGNIFICANCE FOR THE B-Z TRANSITION

被引：9

作者：

CHEN, YZ ^{[1
]}

PROHOFSKY, EW ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT PHYS,1396 PHYS BLDG,W LAFAYETTE,IN 47907

来源：

BIOPHYSICAL JOURNAL | 1993年 / 64卷 / 05期

关键词：

D O I：

10.1016/S0006-3495(93)81505-4

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We calculate room temperature thermal fluctuational base pair opening probabilities of B and Z DNA Poly[d(G-C)] at various salt concentrations and discuss the significance of thermal fluctuation in facilitating base pair disruption during B to Z transition. Our calculated base pair opening probability of the B DNA at lower salt concentrations and the probability of the Z DNA at high salt concentrations are in agreement with observations. The salt dependence of the probabilities indicates a B to Z transition at a salt concentration close to the observed concentration. © 1993, The Biophysical Society. All rights reserved.

引用

页码：1394 / 1397

页数：4

共 15 条

[1]

Chandrasekaran R., 1989, LANDOLT BO RNSTEIN N, P31

[2] PREMELTING THERMAL FLUCTUATIONAL BASE PAIR OPENING PROBABILITY OF POLY(DA).POLY(DT) AS PREDICTED BY THE MODIFIED SELF-CONSISTENT PHONON THEORY [J].

CHEN, YZ ;

FENG, Y ;

PROHOFSKY, EW .

BIOPOLYMERS, 1991, 31 (02) :139-148

[3] SALT-DEPENDENT STABILITY OF POLY(DG) POLY(DC) WITH POTENTIAL OF MEAN FORCE COULOMB INTERACTIONS [J].

CHEN, YZ ;

ZHUANG, W ;

PROHOFSKY, EW .

BIOPOLYMERS, 1992, 32 (08) :1123-1127

[4]

CHEN YZ, 1992, IN PRESS BIOPOLYMERS

[5] DNA STRUCTURAL DYNAMICS - LONGITUDINAL BREATHING AS A POSSIBLE MECHANISM FOR THE B-REVERSIBLE-Z TRANSITION [J].

HARVEY, SC .

NUCLEIC ACIDS RESEARCH, 1983, 11 (14) :4867-4878

[6] A MOLECULAR-DYNAMICS SIMULATION OF A POLYAMINE-INDUCED CONFORMATIONAL CHANGE OF DNA - A POSSIBLE MECHANISM FOR THE B TO Z TRANSITION [J].

HAWORTH, IS ;

RODGER, A ;

RICHARDS, WG .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1992, 10 (01) :195-211

[7] INCLUSION OF IONIC INTERACTIONS IN FORCE-FIELD CALCULATIONS OF CHARGED BIOMOLECULES DNA STRUCTURAL TRANSITIONS [J].

KLEMENT, R ;

SOUMPASIS, DM ;

KITZING, EV ;

JOVIN, TM .

BIOPOLYMERS, 1990, 29 (6-7) :1089-1103

[8] PROCESSES OF BASE-PAIR OPENING AND PROTON-EXCHANGE IN Z-DNA [J].

KOCHOYAN, M ;

LEROY, JL ;

GUERON, M .

BIOCHEMISTRY, 1990, 29 (20) :4799-4805

[9]

LU KC, 1977, BIOPOLYMERS, V16, P2491, DOI 10.1002/bip.1977.360161112

[10] DC-DG ALTERNATING OLIGONUCLEOTIDES - THERMODYNAMIC AND KINETIC ASPECTS OF THE B-Z TRANSFORMATION [J].

MANZINI, G ;

XODO, LE ;

QUADRIFOGLIO, F ;

VANBOOM, JH ;

VANDERMAREL, GA .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1987, 4 (04) :651-662

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