THE SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 2-PARA-QUATERNARY AMMONIOMETHYLPHENYL-CARBAPENEMS

被引：8

作者：

DININNO, F

MUTHARD, DA

SALZMANN, TN

机构：

[1] Merck Research Laboratories Department of Synthetic Chemical Research, Rahway, NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80923-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and in vitro antibacterial activity of 2-phenylcarbapenems bearing a spacer linked heteroaromatic or heterocyclic quaternized moiety are discussed. In general, this class of antibiotics was found to possess antibacterial activity superior to the parent natural product, thienamycin, except for Ps. aeruginosa, and were less susceptible to degradation by the DHP-1 enzyme.

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页码：2187 / 2192

页数：6

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