CYTOKINE-MEDIATED EFFECTS IN MUCOSAL IMMUNITY

被引：59

作者：

KRAMER, DR ^{[1
]}

SUTHERLAND, RM ^{[1
]}

BAO, S ^{[1
]}

HUSBAND, AJ ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT VET PATHOL,SYDNEY,NSW 2006,AUSTRALIA

来源：

IMMUNOLOGY AND CELL BIOLOGY | 1995年 / 73卷 / 05期

关键词：

CYTOKINE THERAPY; CYTOKINES; IGA; MUCOSAL IMMUNITY;

D O I：

10.1038/icb.1995.61

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The predominance of IgA antibodies in mucosal sites reflects a combination of high rate IgA isotype switching among precursor cells in induction sites, their selective localization in mucosal effector tissues and vigorous proliferation of these cells after extravasation. Each of these steps leading to IgA expression at the mucosa is under cytokine control. This paper will address the role of cytokines in induction and expression of IgA responses and strategies for manipulating cytokine expression. Therapeutic interventions based on this information may not only lead to improved vaccination responses and correction of immunodeficiencies but also, by invoking the phenomenon of oral tolerance, may assist in the management of autoimmune, allergic and alloreactive disease.

引用

页码：389 / 396

页数：8

共 71 条

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