ATTENUATED INHIBITION BY LEVOFLOXACIN, L-ISOMER OF OFLOXACIN, ON GABA RESPONSE IN THE DISSOCIATED RAT HIPPOCAMPAL-NEURONS

被引：14

作者：

IMANISHI, T

AKAHANE, K

AKAIKE, N

机构：

[1] KYUSHU UNIV, FAC MED, DEPT PHYSIOL, FUKUOKA 81282, JAPAN

[2] DAIICHI PHARMACEUT CO LTD, EXPLORATORY RES LABS 1, TOKYO 134, JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 193卷 / 02期

关键词：

QUINOLONE; OFLOXACIN; LEVOFLOXACIN; BIPHENYLACETIC ACID; GABA-INDUCED CL- CURRENT; HIPPOCAMPAL NEURON;

D O I：

10.1016/0304-3940(95)11670-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The effects of ofloxacin (OFLX) and its isomers, levofloxacin (LVFX) and DR-3354, on the gamma-aminobutyric acid (GABA)-induced Cl- current in acutely dissociated rat hippocampal CA1 neurons were investigated using nystatin perforated patch recording configuration under voltage-clamp conditions. At 10(-5) M these 3 compounds themselves did not affect the GABA response. Biphenylacetic acid (BPA) at 10(-5) M also had no effect on the GABA response, but BPA greatly suppressed the GABA response in combination with these 3 compounds without affecting the reversal potential of GABA response. The inhibitory effects of OFLX and DR-3354 on the GABA response were stronger than that of LVFX. LVFX inhibited the response in a competitive and voltage-independent manner. The results suggest that LVFX has lower CNS adverse effects, such as convulsions, compared to OFLX.

引用

页码：81 / 84

页数：4

共 21 条

[1]

LEVOFLOXACIN, AN OPTICAL ISOMER OF OFLOXACIN, HAS ATTENUATED EPILEPTOGENIC ACTIVITY IN MICE AND INHIBITORY POTENCY IN GABA RECEPTOR-BINDING [J].