CELL-VOLUME REGULATED TRANSPORTERS OF COMPATIBLE OSMOLYTES

被引：129

作者：

KWON, HM

HANDLER, JS

机构：

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 04期

关键词：

D O I：

10.1016/0955-0674(95)80002-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Virtually all cells respond to hypertonicity by accumulating certain small organic solutes (compatible osmolytes) that, in contrast to intracellular ions, do not perturb macromolecular function. Several important compatible osmolytes are accumulated by coupled transport. Transcription of genes encoding these cotransporters is increased by hypertonicity and a tonicity-responsive enhancer element has been identified. When cells return to an iso-osmotic environment, osmolytes are rapidly lost through a pathway that current evidence indicates may be a volume-sensitive chloride channel.

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页码：465 / 471

页数：7

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