MECHANISM FOR SLOW-BINDING INHIBITION OF HUMAN-LEUKOCYTE ELASTASE BY VALINE-DERIVED BENZOXAZINONES

被引：64

作者：

STEIN, RL

STRIMPLER, AM

VISCARELLO, BR

WILDONGER, RA

MAUGER, RC

TRAINOR, DA

机构：

[1] STUART PHARMACEUT,DEPT MED CHEM,WILMINGTON,DE 19897

[2] STUART PHARMACEUT,DEPT PHARMACOL,WILMINGTON,DE 19897

来源：

BIOCHEMISTRY | 1987年 / 26卷 / 13期

关键词：

D O I：

10.1021/bi00387a057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

收藏

页码：4126 / 4130

页数：5

相关论文

共 16 条

[1] THE DETERMINATION OF ENZYME INHIBITOR CONSTANTS
DIXON, M
[J]. BIOCHEMICAL JOURNAL, 1953, 55 (01) : 170 - 171
[2] DUTTA AS, 1986, Patent No. 4596789
[3] NEW MECHANISM-BASED SERINE PROTEASE INHIBITORS - INHIBITION OF HUMAN-LEUKOCYTE ELASTASE, PORCINE PANCREATIC ELASTASE, HUMAN-LEUKOCYTE CATHEPSIN-G, AND CHYMOTRYPSIN BY 3-CHLOROISOCOUMARIN AND 3,3-DICHLOROPHTHALIDE
HARPER, JW
HEMMI, K
POWERS, JC
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (21) : 6518 - 6520
[4] SUICIDE INACTIVATION OF CHYMOTRYPSIN BY BENZOXAZINONES
HEDSTROM, L
MOORMAN, AR
DOBBS, J
ABELES, RH
[J]. BIOCHEMISTRY, 1984, 23 (08) : 1753 - 1759
[5] MAUREL P, 1978, J BIOL CHEM, V253, P1677
[6] THE SLOW-BINDING AND SLOW, TIGHT-BINDING INHIBITION OF ENZYME-CATALYZED REACTIONS
MORRISON, JF
[J]. TRENDS IN BIOCHEMICAL SCIENCES, 1982, 7 (03) : 102 - 105
[7] NAKAJIMA K, 1979, J BIOL CHEM, V254, P4027
[8] POWERS JC, 1984, J BIOL CHEM, V259, P4288
[9] CATALYSIS BY HUMAN-LEUKOCYTE ELASTASE - SUBSTRATE STRUCTURAL DEPENDENCE OF RATE-LIMITING PROTOLYTIC CATALYSIS AND OPERATION OF THE CHARGE RELAY SYSTEM
STEIN, RL
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (15) : 5111 - 5116
[10] CATALYSIS BY HUMAN-LEUKOCYTE ELASTASE .3. STEADY-STATE KINETICS FOR THE HYDROLYSIS OF PARA-NITROPHENYL ESTERS
STEIN, RL
[J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 236 (02) : 677 - 680