DOWN-REGULATION OF PROTEIN-KINASE-C BLOCKS 5-HT-INDUCED ENHANCEMENT IN HERMISSENDA-B PHOTORECEPTORS

被引：17

作者：

CROW, T ^{[1
]}

FORRESTER, J ^{[1
]}

WILLIAMS, M ^{[1
]}

WAXHAM, MN ^{[1
]}

NEARY, JT ^{[1
]}

机构：

[1] UNIV MIAMI,SCH MED,DEPT PATHOL,VET ADM MED CTR,NEUROPATHOL LAB,MIAMI,FL 33101

来源：

NEUROSCIENCE LETTERS | 1991年 / 121卷 / 1-2期

关键词：

PROTEIN KINASE-C; SEROTONIN; ENHANCEMENT; HERMISSENDA;

D O I：

10.1016/0304-3940(91)90660-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Light paired with serotonin (5-HT) in vivo produces both short and long-term enhancement of generator potentials in identified B-photoreceptors in Hermissenda. The contribution of protein kinase C to the induction of enhancement was assessed by pretreatment with 12-O-tetradecanoyl-phorbol-13-acetate (TPA), which produces a depletion or down-regulation of protein kinase C. Presentation of light and 5-HT after an 8 h pretreatment with TPA blocked the induction of enhancement of light-evoked generator potentials. Typical enhancement produced by light and 5-HT was observed after pretreatment with an inactive phorbol (4-alpha-phorbol). These results indicate that activation of protein kinase C is an important step in the induction of enhancement.

引用

页码：107 / 110

页数：4

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