DECREASED UPTAKE AND BINDING OF C-11 NICOTINE IN BRAIN OF ALZHEIMER PATIENTS AS VISUALIZED BY POSITRON EMISSION TOMOGRAPHY

被引：128

作者：

NORDBERG, A

HARTVIG, P

LILJA, A

VIITANEN, M

AMBERLA, K

LUNDQVIST, H

ANDERSSON, Y

ULIN, J

WINBLAD, B

LANGSTROM, B

机构：

[1] UNIV UPPSALA, DEPT PHARMACOL, BOX 591, S-75124 UPPSALA, SWEDEN

[2] KAROLINSKA INST, HUDDINGE HOSP, DEPT GERIAT MED, S-10401 STOCKHOLM 60, SWEDEN

[3] UNIV UPPSALA, DEPT ORGAN CHEM, S-75105 UPPSALA, SWEDEN

[4] UNIV UPPSALA, DEPT DIAGNOST RADIOL, S-75105 UPPSALA, SWEDEN

[5] UNIV UPPSALA, SVEDBERG LAB, S-75105 UPPSALA, SWEDEN

[6] UNIV UPPSALA HOSP, HOSP PHARM, S-75014 UPPSALA, SWEDEN

来源：

JOURNAL OF NEURAL TRANSMISSION-PARKINSONS DISEASE AND DEMENTIA SECTION | 1990年 / 2卷 / 03期

关键词：

(+) (R) N-[!sup]11[!/sup]C-methyl nicotine; (-) (S) N-[!sup]11[!/sup]C-methyl nicotine; Alzheimer's disease; brain; cholinergic receptors; diagnostic marker; nicotinic receptors; PET; Positron emission tomography;

D O I：

10.1007/BF02257652

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Positron emission tomography of the brain following intravenous injection of (+) (R) and (-) (S) N-[11C-methyl]nicotine showed a marked reduced uptake of both isomers, especially the (R) form, in Alzheimer patients as compared to age-matched controls. The significantly larger difference between the uptake values of the (S)- and (R)-enantiomers of11C-nicotine in Azheimer brains may be of diagnostic value. © 1990 Springer-Verlag.

引用

页码：215 / 224

页数：10

共 41 条

[1] BINDING OF OPTICALLY PURE (-)-[H-3] NICOTINE TO RAT-BRAIN MEMBRANES [J].