INCREASED RESISTANCE TO MULTIPLE-DRUGS BY INTRODUCTION OF THE ENTEROBACTER-CLOACAE-ROMA GENE INTO OMPF PORIN-DEFICIENT MUTANTS OF ESCHERICHIA-COLI K-12

被引：7

作者：

KOMATSU, T ^{[1
]}

OHTA, M ^{[1
]}

KIDO, N ^{[1
]}

ARAKAWA, Y ^{[1
]}

ITO, H ^{[1
]}

KATO, N ^{[1
]}

机构：

[1] NAGOYA UNIV,SCH MED,DEPT BACTERIOL,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 10期

关键词：

D O I：

10.1128/AAC.35.10.2155

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Introduction of the romA gene cloned from Enterobacter cloacae into Escherichia coli K-12 resulted in almost complete inhibition of OmpF expression and a concomitant increase in resistance to quinolones, beta-lactams, chloramphenicol, and tetracyclines. In addition, the romA gene reduced the susceptibility to these multiple drugs even in the OmpF porin-deficient mutants of E. coli K-12. Results indicate the presence of romA-sensitive penetration pathway(s) for these multiple drugs other than the OmpF porin in E. coli.

引用

页码：2155 / 2158

页数：4

共 27 条

[1] CO-REGULATION IN ESCHERICHIA-COLI OF A NOVEL TRANSPORT-SYSTEM FOR SN-GLYCEROL-3-PHOSPHATE AND OUTER-MEMBRANE PROTEIN IC (E, E) WITH ALKALINE-PHOSPHATASE AND PHOSPHATE-BINDING PROTEIN [J].

ARGAST, M ;

BOOS, W .

JOURNAL OF BACTERIOLOGY, 1980, 143 (01) :142-150

[2] ACCUMULATION OF ENOXACIN BY ESCHERICHIA-COLI AND BACILLUS-SUBTILIS [J].

BEDARD, J ;

WONG, S ;

BRYAN, LE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (09) :1348-1354

[3] TRANSPOSITION AND FUSION OF LAC GENES TO SELECTED PROMOTERS IN ESCHERICHIA-COLI USING BACTERIOPHAGE-LAMBDA AND BACTERIOPHAGE-MU [J].

CASADABAN, MJ .

JOURNAL OF MOLECULAR BIOLOGY, 1976, 104 (03) :541-555

[4] DIFFUSION OF TETRACYCLINE ACROSS OUTER MEMBRANE OF ESCHERICHIA-COLI K-12 - INVOLVEMENT OF PROTEIN-IA [J].

CHOPRA, I ;

ECCLES, SJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 83 (02) :550-557

[5] CROSS-RESISTANCE TO FLUOROQUINOLONES IN MULTIPLE-ANTIBIOTIC-RESISTANT (MAR) ESCHERICHIA-COLI SELECTED BY TETRACYCLINE OR CHLORAMPHENICOL - DECREASED DRUG ACCUMULATION ASSOCIATED WITH MEMBRANE-CHANGES IN ADDITION TO OMPF REDUCTION [J].

COHEN, SP ;

MCMURRY, LM ;

HOOPER, DC ;

WOLFSON, JS ;

LEVY, SB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (08) :1318-1325

[6] GENE IN THE MAJOR CO-TRANSDUCTION GAP OF THE ESCHERICHIA-COLI K-12 LINKAGE MAP REQUIRED FOR THE EXPRESSION OF CHROMOSOMAL RESISTANCE TO TETRACYCLINE AND OTHER ANTIBIOTICS [J].

GEORGE, AM ;

LEVY, SB .

JOURNAL OF BACTERIOLOGY, 1983, 155 (02) :541-548

[7] MUTANTS OF ESCHERICHIA-COLI THAT ARE RESISTANT TO CERTAIN BETA-LACTAM COMPOUNDS LACK THE OMPF PORIN [J].

HARDER, KJ ;

NIKAIDO, H ;

MATSUHASHI, M .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1981, 20 (04) :549-552

[8] DIFFERENCES IN SUSCEPTIBILITY TO QUINOLONES OF OUTER-MEMBRANE MUTANTS OF SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI [J].

HIRAI, K ;

AOYAMA, H ;

IRIKURA, T ;

IYOBE, S ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (03) :535-538

[9] ISOLATION AND CHARACTERIZATION OF NORFLOXACIN-RESISTANT MUTANTS OF ESCHERICHIA-COLI K-12 [J].

HIRAI, K ;

AOYAMA, H ;

SUZUE, S ;

IRIKURA, T ;

IYOBE, S ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (02) :248-253

[10] EFFECTS OF BETA-LACTAMASES AND OMP MUTATION ON SUSCEPTIBILITY TO BETA-LACTAM ANTIBIOTICS IN ESCHERICHIA-COLI [J].

HIRAOKA, M ;

OKAMOTO, R ;

INOUE, M ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (03) :382-386

← 1 2 3 →