MOLECULAR INSIGHTS INTO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PATHOGENESIS

被引：33

作者：

FEINBERG, MB

GREENE, WC

机构：

[1] Gladstone Institute of Virology and Immunology, University of California, San Francisco

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(06)80041-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection with human immunodeficiency virus type 1 leads to a persistent but progressive cytopathic process that culminates in the near complete destruction of the CD4+ subset of T cells. The levels of human immunodeficiency virus type 1 replication and virus burden increase throughout the clinical course of disease reflecting a balance between the viral and cellular regulatory influences as well as the ability of the host immune system to eliminate infected T cells. Human immunodeficiency virus type 1 replication is dependent on the state of cellular activation and involves both inducible host cell derived transcription factors and at least three virus-derived gene products. Further study of the mechanism of action of these factors, particularly those encoded by the virus, may facilitate the future development of highly specific and effective therapies for human immunodeficiency virus type 1.

引用

收藏

页码：466 / 474

页数：9

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