SELECTIVE HYDROGENOLYSIS OF THE BENZYLOXYCARBONYL PROTECTING GROUP OF N-EPSILON-LYSINE IN CYCLOPEPTIDES CONTAINING A BENZYLIC PHENYL ETHER FUNCTION - EVIDENCE FOR N-EPSILON-METHYLATED LYSINE SIDE PRODUCTS

被引：19

作者：

MAZALEYRAT, JP

XIE, J

WAKSELMAN, M

机构：

[1] CNRS-CERCOA, F-94320 Thiais, 2, rue Henri Dunant

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(00)74244-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Selective hydrogenolytic cleavage of the N(epsilon)-Z protecting group of lysine in cyclopeptides c[-(Glycyl)n-A-B-N(epsilon)-Z-Lysyl-2-Phenoxymethyl-5-Aminobenzoyl-] (A = B = Glycyl, n = 2 or A = Phenylalanyl, B = Alanyl, n = 2 and 3) occured in both acidic (MeOH/aq.AcOH) and neutral (MeOH/DMF) solvents, with Pd/C catalyst. In the latter case, a N(epsilon)-(bis)-methylated lysine side product was isolated.

引用

页码：4301 / 4302

页数：2