THE AUTOANTIGEN KU IS INDISTINGUISHABLE FROM NF IV, A PROTEIN FORMING MULTIMERIC PROTEIN-DNA COMPLEXES

被引：45

作者：

STUIVER, MH ^{[1
]}

COENJAERTS, FEJ ^{[1
]}

VANDERVLIET, PC ^{[1
]}

机构：

[1] STATE UNIV UTRECHT,PHYSIOL CHEM LAB,VONDELLAAN 24A,3521 GG UTRECHT,NETHERLANDS

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 04期

关键词：

D O I：

10.1084/jem.172.4.1049

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have isolated a cDNA encoding the 84-kD subunit of NFIV. Tryptic peptide sequences were identified within the coding sequences, confirming its proper identity. The primary sequence of the protein is identical to that of the large subunit of the Ku autoantigen. A missing NFIV peptide sequence was identified within the sequence of the small subunit of Ku. In addition, the proteins are identical in immunological aspects. We suggest that the Ku and NFIV proteins are identical. This connection adds new biochemical data to our knowledge ofthe Ku autoantigen. © 1990, Rockefeller University Press., All rights reserved.

引用

页码：1049 / 1054

页数：6

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