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EFFECT OF METHYL SUBSTITUTION ON THE IRRITANCY OF DIBENZ[B,F]1,4-OXAZEPINE (CR)
被引:1
作者
:
GREEN, DM
论文数:
0
引用数:
0
h-index:
0
机构:
Biology Division, Chemical Defence Establishment, Salisbury, Wilts SP4 0JQ, Porton Down
GREEN, DM
BALFOUR, DJK
论文数:
0
引用数:
0
h-index:
0
机构:
Biology Division, Chemical Defence Establishment, Salisbury, Wilts SP4 0JQ, Porton Down
BALFOUR, DJK
MUIR, A
论文数:
0
引用数:
0
h-index:
0
机构:
Biology Division, Chemical Defence Establishment, Salisbury, Wilts SP4 0JQ, Porton Down
MUIR, A
机构
:
[1]
Biology Division, Chemical Defence Establishment, Salisbury, Wilts SP4 0JQ, Porton Down
来源
:
TOXICOLOGY
|
1979年
/ 12卷
/ 02期
关键词
:
D O I
:
10.1016/0300-483X(79)90041-6
中图分类号
:
R9 [药学];
学科分类号
:
1007 ;
摘要
:
The irritant properties of 3 methylated derivatives of dibenz[b,f]1,4-oxizepine (CR) have been investigated, using the guinea-pig blepharospasm test and isolated cat eye preparations, and compared with the irritancy of the unsubstituted CR molecule. In both tests, the 11-methyl derivative was non-irritant whereas 3 Me-CR retained some irritancy although both were less potent than CR itself. The possible significance of these results are discussed in relation of earlier biochemical studies. © 1979.
引用
收藏
页码:151 / 153
页数:3
相关论文
共 4 条
[1]
STUDIES ON UPTAKE AND METABOLISM OF DIBENZ(B,F)-1,4-OXAZEPINE (CR) BY GUINEA-PIG CORNEA
BALFOUR, DJK
论文数:
0
引用数:
0
h-index:
0
机构:
CHEM DEF ESTAB,DIV BIOL,SALISBURY SP4 0JQ,WILTSHIRE,ENGLAND
CHEM DEF ESTAB,DIV BIOL,SALISBURY SP4 0JQ,WILTSHIRE,ENGLAND
BALFOUR, DJK
[J].
TOXICOLOGY,
1978,
9
(1-2)
: 11
-
20
[2]
BALLANTYNE B, 1974, Acta Pharmacologica et Toxicologica, V35, P412
[3]
GREEN DM, 1964, J PHYSIOL-LONDON, V175, pP37
[4]
SENSORY NERVES OF THE CORNEA AND CUTANEOUS SENSIBILITY
LELE, PP
论文数:
0
引用数:
0
h-index:
0
LELE, PP
WEDDELL, G
论文数:
0
引用数:
0
h-index:
0
WEDDELL, G
[J].
EXPERIMENTAL NEUROLOGY,
1959,
1
(04)
: 334
-
359
←
1
→
共 4 条
[1]
STUDIES ON UPTAKE AND METABOLISM OF DIBENZ(B,F)-1,4-OXAZEPINE (CR) BY GUINEA-PIG CORNEA
BALFOUR, DJK
论文数:
0
引用数:
0
h-index:
0
机构:
CHEM DEF ESTAB,DIV BIOL,SALISBURY SP4 0JQ,WILTSHIRE,ENGLAND
CHEM DEF ESTAB,DIV BIOL,SALISBURY SP4 0JQ,WILTSHIRE,ENGLAND
BALFOUR, DJK
[J].
TOXICOLOGY,
1978,
9
(1-2)
: 11
-
20
[2]
BALLANTYNE B, 1974, Acta Pharmacologica et Toxicologica, V35, P412
[3]
GREEN DM, 1964, J PHYSIOL-LONDON, V175, pP37
[4]
SENSORY NERVES OF THE CORNEA AND CUTANEOUS SENSIBILITY
LELE, PP
论文数:
0
引用数:
0
h-index:
0
LELE, PP
WEDDELL, G
论文数:
0
引用数:
0
h-index:
0
WEDDELL, G
[J].
EXPERIMENTAL NEUROLOGY,
1959,
1
(04)
: 334
-
359
←
1
→