EFFECT OF METHYL SUBSTITUTION ON THE IRRITANCY OF DIBENZ[B,F]1,4-OXAZEPINE (CR)

被引:1
作者
GREEN, DM
BALFOUR, DJK
MUIR, A
机构
[1] Biology Division, Chemical Defence Establishment, Salisbury, Wilts SP4 0JQ, Porton Down
关键词
D O I
10.1016/0300-483X(79)90041-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The irritant properties of 3 methylated derivatives of dibenz[b,f]1,4-oxizepine (CR) have been investigated, using the guinea-pig blepharospasm test and isolated cat eye preparations, and compared with the irritancy of the unsubstituted CR molecule. In both tests, the 11-methyl derivative was non-irritant whereas 3 Me-CR retained some irritancy although both were less potent than CR itself. The possible significance of these results are discussed in relation of earlier biochemical studies. © 1979.
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页码:151 / 153
页数:3
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