DIFFERENTIAL REGULATION OF ESTROGEN-DEPENDENT SEXUAL DEVELOPMENT OF RAT-BRAIN BY GROWTH-FACTORS

被引：11

作者：

HASEGAWA, N ^{[1
]}

TAKEO, T ^{[1
]}

SAKUMA, Y ^{[1
]}

机构：

[1] HIROSAKI UNIV,SCH MED,DEPT PHYSIOL 1,HIROSAKI,AOMORI 036,JAPAN

来源：

NEUROSCIENCE LETTERS | 1991年 / 123卷 / 02期

关键词：

ESTROGEN; LORDOSIS; NERVE GROWTH FACTOR; LUTEINIZING HORMONE; SEXUAL DIFFERENCE;

D O I：

10.1016/0304-3940(91)90926-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Intraventricular infusion of antiserum to nerve growth factor (ANGF), but not that to insulin, epidermal growth factor nor normal rabbit serum, resisted estrogen-induced behavioral defeminization in the female rat neonates. A significant number of the ANGF-treated rats showed lordosis as adults despite neonatal estrogen, but positive feedback of estrogen on serum luteinizing hormone was absent. Sexual phenotype in behavioral and gonadotropic functions may be under differential developmental regulation.

引用

页码：183 / 186

页数：4

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