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VIRULENCE OF RIMANTADINE-RESISTANT HUMAN INFLUENZA-A (H3N2) VIRUSES IN FERRETS

被引：50
作者：
SWEET, C
HAYDEN, FG
JAKEMAN, KJ
GRAMBAS, S
HAY, AJ
机构：
[1] NATL INST MED RES,DIV VIROL,RIDGEWAY,MILL HILL,LONDON NW7 1AA,ENGLAND
[2] UNIV BIRMINGHAM,SCH BIOL SCI,MICROBIAL MOLEC GENET & CELL BIOL GRP,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND
[3] UNIV VIRGINIA,MED CTR,SCH MED,DEPT MED & PATHOL,CHARLOTTESVILLE,VA 22901
来源：
JOURNAL OF INFECTIOUS DISEASES | 1991年 / 164卷 / 05期
关键词：
D O I：
10.1093/infdis/164.5.969
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, and 31, within the M2 sequence and their corresponding sensitive wild-type isolates contrasted with differences in virulence between the three pairs of viruses. These data provide further evidence that rimantadine-resistant viruses that emerge during treatment of patients with the drug are unaltered both in their growth characteristics and virulence.
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页码：969 / 972
页数：4
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