MIXED HAPLOTYPES AND AUTOIMMUNITY

被引：42

作者：

NYGARD, NR

MCCARTHY, DM

SCHIFFENBAUER, J

SCHWARTZ, BD

机构：

[1] AMOCO RES & DEV, NAPERVILLE, IL 60566 USA

[2] UNIV FLORIDA, DEPT MED, GAINESVILLE, FL 32610 USA

[3] MONSANTO CO, CORP RES, DEPT IMMUNOL, ST LOUIS, MO 63198 USA

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 02期

关键词：

D O I：

10.1016/0167-5699(93)90058-S

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Why do (NZB x NZW)F1 mice develop an autoimmune lupus-like syndrome? The second exons of the class II genes of NZB and NZW are identical to their counterparts of H-2d and H-2u haplotypes. Several lines of evidence suggest that this allows the production of a mixed haplotype molecule, I-Ealpha(d)Ebeta(z), and that this molecule plays a key role in the development of autoimmunity.

引用

页码：53 / 56

页数：4

共 28 条

[1] THE 1ST EXTERNAL DOMAIN OF THE NONOBESE DIABETIC MOUSE CLASS-II I-A BETA-CHAIN IS UNIQUE
ACHAORBEA, H
MCDEVITT, HO
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) : 2435 - 2439
[2] TREATMENT OF (NZBXNZW)F1 DISEASE WITH ANTI-I-A MONOCLONAL-ANTIBODIES
ADELMAN, NE
WATLING, DL
MCDEVITT, HO
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1983, 158 (04) : 1350 - 1355
[3] AYANE M, 1986, J IMMUNOL, V137, P948
[4] ALLELE-SPECIFIC CONTROL OF IA MOLECULE SURFACE EXPRESSION AND CONFORMATION - IMPLICATIONS FOR A GENERAL-MODEL OF IA STRUCTURE-FUNCTION-RELATIONSHIPS
BRAUNSTEIN, NS
GERMAIN, RN
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (09) : 2921 - 2925
[5] CHANG BL, 1990, J IMMUNOL, V145, P94
[6] THE EXPRESSION OF I-ED MOLECULES IN F1-HYBRID MICE DETECTED WITH ANTIGEN-SPECIFIC, I-ED-RESTRICTED CLONED T-CELL LINES
CONRAD, PJ
JANEWAY, CA
[J]. IMMUNOGENETICS, 1984, 20 (03) : 311 - 319
[7] STUDIES UTILIZING MURINE T-CELL CLONES - IR GENES, IA ANTIGENS AND MLR STIMULATING DETERMINANTS
FATHMAN, CG
KIMOTO, M
[J]. IMMUNOLOGICAL REVIEWS, 1981, 54 : 57 - 79
[8] FUNCTIONAL EXPRESSION OF A TRANSFECTED MURINE CLASS-II MHC GENE
GERMAIN, RN
NORCROSS, MA
MARGULIES, DH
[J]. NATURE, 1983, 306 (5939) : 190 - 194
[9] INFLUENCE OF ALLELIC POLYMORPHISM ON THE ASSEMBLY AND SURFACE EXPRESSION OF CLASS-II MHC (LA) MOLECULES
GERMAIN, RN
BENTLEY, DM
QUILL, H
[J]. CELL, 1985, 43 (01) : 233 - 242
[10] THE NOD MOUSE - RECESSIVE DIABETOGENIC GENE IN THE MAJOR HISTOCOMPATIBILITY COMPLEX
HATTORI, M
BUSE, JB
JACKSON, RA
GLIMCHER, L
DORF, ME
MINAMI, M
MAKINO, S
MORIWAKI, K
KUZUYA, H
IMURA, H
STRAUSS, WM
SEIDMAN, JG
EISENBARTH, GS
[J]. SCIENCE, 1986, 231 (4739) : 733 - 735

← 1 2 3 →