THE ACUTE ACTIONS OF GROWTH-FACTORS IN SMOOTH-MUSCLE SYSTEMS

被引:36
作者
HOLLENBERG, MD [1 ]
机构
[1] UNIV CALGARY,FAC MED,DEPT MED,CALGARY T2N 4N1,AB,CANADA
关键词
D O I
10.1016/0024-3205(94)00811-6
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Work over the past six to eight years has established that mitogenic polypeptides such as epidermal growth factor-urogastrone (EGF-URO) or platelet-derived growth factor (PDGF), commonly referred to as 'growth factors', can have rapid (seconds to minutes) regulatory actions in a variety of smooth muscle systems. With EGF-URO as a prototype example, this article describes three distinct smooth muscle response paradigms, two of which (type A and type B) comprise a rapid (seconds to minutes) increase in muscle tension) and one of which (type C) is characterized by an EGF-URO-mediated reduction in sensitivity to other agonists. The quite distinct signal transduction pathways for the three types of response paradigms are outlined, and the marked tissue and species variation in the types of smooth muscle responses that can be observed, even for a single growth factor agonist, are summarized. The article also illustrates that G-protein-coupled vasoactive agents such as angiotensin-II and vasopressin, which can act as 'growth factors' in cultured cell systems, can also work via tyrosine kinase pathways to cause contraction in some of the same intact smooth muscle preparations that contract in response to growth factors such as EGF-URO. Attention is drawn to the fact that many so-called 'growth factors', quite apart from stimulating cell division and differentiation, may in many instances act as rapid localized paracrine/autocrine regulators of tissues such as smooth muscle. It is also pointed out that some of the tyrosine kinase-modulated signal pathways usually associated with the mitogenic action of 'growth factors' may be involved not only in the rapid effects of agents such as EGF-URO in smooth muscle but also in the contractile actions of G-protein-linked agonists.
引用
收藏
页码:223 / 235
页数:13
相关论文
共 32 条
[1]   PURIFICATION OF HUMAN PLATELET-DERIVED GROWTH-FACTOR [J].
ANTONIADES, HN ;
SCHER, CD ;
STILES, CD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (04) :1809-1813
[2]   EPIDERMAL GROWTH-FACTOR, A VASCULAR SMOOTH-MUSCLE MITOGEN, INDUCES RAT AORTIC CONTRACTION [J].
BERK, BC ;
BROCK, TA ;
WEBB, RC ;
TAUBMAN, MB ;
ATKINSON, WJ ;
GIMBRONE, MA ;
ALEXANDER, RW .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (03) :1083-1086
[3]   VASOACTIVE EFFECTS OF GROWTH-FACTORS [J].
BERK, BC ;
ALEXANDER, RW .
BIOCHEMICAL PHARMACOLOGY, 1989, 38 (02) :219-225
[4]   VASOCONSTRICTION - A NEW ACTIVITY FOR PLATELET-DERIVED GROWTH-FACTOR [J].
BERK, BC ;
ALEXANDER, RW ;
BROCK, TA ;
GIMBRONE, MA ;
WEBB, RC .
SCIENCE, 1986, 232 (4746) :87-90
[5]  
CARPENTER G, 1990, J BIOL CHEM, V265, P7709
[6]   CIRCULATORY EFFECTS OF A DEPILATORY DOSE OF MOUSE EPIDERMAL GROWTH-FACTOR IN SHEEP [J].
CARTER, NB ;
FAWCETT, AA ;
HALES, JRS ;
MOORE, GPM ;
PANARETTO, BA .
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 403 :27-39
[7]  
COHEN S, 1962, J BIOL CHEM, V237, P1555
[8]   PLATELET-DERIVED GROWTH-FACTOR RECEPTORS ON MACROVASCULAR ENDOTHELIAL-CELLS MEDIATE RELAXATION VIA NITRIC-OXIDE IN RAT AORTA [J].
CUNNINGHAM, LD ;
BRECHER, P ;
COHEN, RA .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (03) :878-882
[9]   TYROSINE KINASE INHIBITORS SUPPRESS AGONIST-INDUCED CONTRACTION IN SMOOTH-MUSCLE [J].
DISALVO, J ;
STEUSLOFF, A ;
SEMENCHUK, L ;
SATOH, S ;
KOLQUIST, K ;
PFITZER, G .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 190 (03) :968-974
[10]   CALCIUM AND ANGIOTENSIN TACHYPHYLAXIS IN RAT UTERINE SMOOTH-MUSCLE [J].
FREER, RJ .
AMERICAN JOURNAL OF PHYSIOLOGY, 1975, 228 (05) :1423-1430