STRUCTURE-ACTIVITY-RELATIONSHIPS OF NONPEPTIDE BRADYKININ B-2 RECEPTOR ANTAGONISTS

被引：8

作者：

SALVINO, JM ^{[1
]}

SEOANE, PR ^{[1
]}

DOUTY, BD ^{[1
]}

AWAD, MA ^{[1
]}

HOYER, D ^{[1
]}

ROSS, TM ^{[1
]}

DOLLE, RE ^{[1
]}

HOUCK, WT ^{[1
]}

FAUNCE, DM ^{[1
]}

SAWUTZ, DG ^{[1
]}

机构：

[1] STERLING WINTHROP PHARMACEUT RES DIV,DEPT BIOCHEM,COLLEGEVILLE,PA 19426

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 04期

关键词：

D O I：

10.1016/0960-894X(95)00035-R

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of non-peptide competitive antagonists of the human IMR 90 fetal lung fibroblast bradykinin B-2 receptor have been designed and synthesized. Compound 15 binds with an affinity constant K-i = 60 nM. The SAR leading to the design of these non-peptide antagonists is described.

引用

页码：357 / 362

页数：6

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