EFFECT OF GAMMA-HYDROXYBUTYRATE AND ITS ANTAGONIST NCS-382 ON SPONTANEOUS CELL FIRING IN THE PREFRONTAL CORTEX OF THE RAT

被引：47

作者：

GODBOUT, R

JELENIC, P

LABRIE, C

SCHMITT, M

BOURGUIGNON, JJ

机构：

[1] UNIV MONTREAL, DEPT PSYCHIAT, MONTREAL, PQ H3C 3J7, CANADA

[2] CNRS, UPR 421, PHARMACOCHIM MOLEC LAB, STRASBOURG, FRANCE

来源：

BRAIN RESEARCH | 1995年 / 673卷 / 01期

关键词：

GAMMA-HYDROXYBUTYRATE; PREFRONTAL CORTEX; ELECTROPHYSIOLOGY; DOPAMINE; SLEEP; NARCOLEPSY; ALCOHOL; ABUSE;

D O I：

10.1016/0006-8993(94)01461-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gamma-hydroxybutyrate (GHB) at low doses (5-10 mg/kg i.p.) increased and at high doses (160-320 mg/kg i.p.) decreased the spontaneous firing rate of prefrontal cortex (PFC) neurons recorded in urethane-anesthetized rats. Only excitations were blocked by NCS-382, a specific GHB receptor antagonist; this suggests that the excitatory effect of low doses of GHB is mediated by a GHB receptor whereas the inhibitory effect of high doses of GHB involves a more complex mechanism.

引用

收藏

页码：157 / 160

页数：4

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