AMPA, KA AND NMDA RECEPTORS ARE EXPRESSED IN THE RAT DRG NEURONS

被引：178

作者：

SATO, K

KIYAMA, H

PARK, HT

TOHYAMA, M

机构：

[1] OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI,2-2 YAMADAOKA,SUITA,OSAKA 565,JAPAN

[2] OSAKA UNIV,CTR BIOMED EDUC & RES,DEPT NEUROANAT,SUITA,OSAKA 565,JAPAN

来源：

NEUROREPORT | 1993年 / 4卷 / 11期

关键词：

GLUR1-5; AMPA RECEPTOR; KA RECEPTOR; NMDA RECEPTOR; NOCICEPTION; GLUTAMATE; DORSAL ROOT GANGLION;

D O I：

10.1097/00001756-199309000-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE localization of AMPA receptor subunits (GluR1-4), a KA receptor subunit (GluR5) and NMDA receptor subunits (NR1 and NRgbs; the glutamate binding subunits of an NMDA receptor complex) was investigated using immunohistochemistry and in situ hybridization histochemistry in the rat dorsal root ganglion. Small neurones expressed GluR1-, GluR2/3-like immunoreactivities and GluR5, NR1, NRgbs mRNAs, while large neurones expressed GluR2/3-like immunoreactivity and NR1 and NRgbs mRNAs. These data suggest that the glutamatergic system plays an important role in the primary sensory afferent systems and that the composition of glutamate receptors differs according to the cell size.

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页码：1263 / 1265

页数：3

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