EFFECTS OF COCAINE ON CORTISOL SECRETION IN HUMANS

被引：52

作者：

HEESCH, CM

NEGUS, BH

KEFFER, JH

SNYDER, RW

RISSER, RC

EICHHORN, EJ

机构：

[1] UNIV TEXAS,SW MED CTR,DEPT INTERNAL MED,DIV CARDIOL,CARDIAC CATHETERIZAT LAB,DALLAS,TX 75216

[2] UNIV TEXAS,SW MED CTR,DEPT PATHOL,DALLAS,TX 75216

[3] UNIV TEXAS,SW MED CTR,DEPT BIOSTAT,DALLAS,TX 75216

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 1995年 / 310卷 / 02期

关键词：

COCAINE; CORTISOL; ADRENOCORTICOTROPIC HORMONE (ACTH);

D O I：

10.1097/00000441-199508000-00004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of acute cocaine administration on the pituitary adrenal axis in humans without a history of drug abuse are unknown. The authors studied 12 male volunteers twice in a double-blinded, placebo-controlled, randomized fashion. After intranasal administration of 2 mg/kg cocaine, cortisol levels were significantly higher than after placebo administration. The authors concluded that acute administration of cocaine to humans increases cortisol secretion.

引用

页码：61 / 64

页数：4

共 19 条

[1]

BOROWSKY B, 1991, J PHARMACOL EXP THER, V256, P204

[2] COCAINE STIMULATES RAT HYPOTHALAMIC CORTICOTROPIN-RELEASING HORMONE-SECRETION INVITRO [J].