A simple method for calculating enantiomer ratio and equilibrium constants in biocatalytic resolutions

被引：9

作者：

Anthonsen, HW ^{[1
]}

Hoff, BH ^{[1
]}

Anthonsen, T ^{[1
]}

机构：

[1] SINTEF,UNIMED,MR CTR,N-7030 TRONDHEIM,NORWAY

来源：

TETRAHEDRON-ASYMMETRY | 1995年 / 6卷 / 12期

关键词：

D O I：

10.1016/0957-4166(95)00398-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A computer programme for determination of equilibrium constant (K) and enantiomer ratio (E) in biocatalytic resolutions has been developed. The programme utilises experimental data, ee(s) and ee(p) measured at more than one conversion, and determines both K and E no matter whether the reaction is irreversible (K=0) or reversible (K>0). An estimation of errors in the calculations indicates that errors in E does not show a Gaussian distribution, while errors in K does. The usefulness of the programme has been tested in a lipase-catalysed transesterification of 1-phenoxy-2-propanol at various concentrations of acyl donor, with different solvents and at different water activities.

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收藏

页码：3015 / 3022

页数：8

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