COMPARATIVE-ANALYSIS OF THE 5' NONCODING REGION OF PESTIVIRUS RNA DETECTED FROM LIVE VIRUS-VACCINES

被引：29

作者：

HARASAWA, R

机构：

[1] Animal Center for Biomedical Research, Faculty of Medicine, The University of Tokyo, Tokyo 113, Bunkyo-ku

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 1994年 / 56卷 / 05期

关键词：

BOVINE VIRAL DIARRHEA VIRUS; PESTIVIRUS; VACCINE;

D O I：

10.1292/jvms.56.961

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Comparative analysis of nucleotide sequences in the 5' non-coding region (NCR) of pestivirus RNA detected from live porcine and human virus vaccines indicated that the contaminants are of bovine viral diarrhea virus (BVDV), and that there are at least three genotypes, which are distinct from hog cholera virus, among the BVDV strains. Most of the nucleotide changes in variable regions of the 5' NCR were covariant, with complementary substitutions at other positions for secondary structures. The proposed secondary structure in the 5' NCR was similar to the prokaryotic rho independent terminator. Short open reading frames in the 5' NCR were well conserved among pestiviruses.

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页码：961 / 964

页数：4

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