EFFECTS OF PHOSPHATIDYLSERINE THERAPY IN GERIATRIC-PATIENTS WITH DEPRESSIVE-DISORDERS

被引：45

作者：

MAGGIONI, M

PICOTTI, GB

BONDIOLOTTI, GP

PANERAI, A

CENACCHI, T

NOBILE, P

BRAMBILLA, F

机构：

[1] OSPED PSICHIATR P PINI,CTR PSICONEUROENDOCRINOL,VIA IPPOCRATE 45,I-20161 MILAN,ITALY

[2] FIDIA DIREZ RIC CLIN,ABANO TERME,ITALY

[3] CLIN ZUCCHI,CARATE,ITALY

[4] UNIV GENOA,IST FARMACOL,I-16126 GENOA,ITALY

[5] UNIV MILAN,DEPARTIMENTO FARMACOL,I-20122 MILAN,ITALY

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1990年 / 81卷 / 03期

关键词：

adrenoceptor; aging; amine metabolite; depression; noradrenaline; phosphatidylserine;

D O I：

10.1111/j.1600-0447.1990.tb06494.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The effects of phosphatidylserine (BC‐PS) on cognitive, affective and behavioural symptoms were studied in a group of 10 elderly women with depressive disorders. Patients were treated with placebo for 15 days, followed by BC‐PS (300 mg/day) for 30 days. The Hamilton Rating Scale for Depression, Gottfries‐Bråne‐Steen Rating Scale, Nurse's Observation Scale for Inpatient Evaluation and Buschke Selective Reminding Test were administered before and after placebo and after BC‐PS therapy, to monitor changes in depression, memory and general behaviour. At the same time, basal plasma levels of noradrenaline, MHPG, DOPAC, HVA and 5‐HIAA, and GH/β‐endorphin/β‐lipotropin responses to clonidine stimulation were measured. BC‐PS induced consistent improvement of depressive symptoms, memory and behaviour. No changes in amine metabolite levels or in hormonal responses to α2‐adrenoceptor stimulation were observed. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：265 / 270

页数：6

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