DEFECTIVE CALCIUM HANDLING AND INSULIN RELEASE IN ISLETS FROM DIABETIC CHINESE HAMSTERS

被引：26

作者：

SIEGEL, EG ^{[1
]}

WOLLHEIM, CB ^{[1
]}

SHARP, GWG ^{[1
]}

HERBERG, L ^{[1
]}

RENOLD, AE ^{[1
]}

机构：

[1] DIABETES RES INST,DUSSELDORF,FED REP GER

来源：

BIOCHEMICAL JOURNAL | 1979年 / 180卷 / 01期

关键词：

D O I：

10.1042/bj1800233

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In pancreatic islets from normal Chinese hamsters preloaded with 45Ca2+, glucose-induced biphasic insulin release was associated with increased 45Ca2+ efflux; islets from diabetic hamsters showed decreased insulin release and no increase in 45Ca2+ efflux. The lack of stimulated 45Ca2+ efflux persisted even when glucose-induced insulin release was potentiated by 3-isobutyl-1-methylxanthine. Since glucose-stimulated 45Ca2+ uptake by diabetic islets was not impaired, a defect in intracellular Ca2+ handling may be involved in the defective insulin release of the diabetic Chinese hamster.

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页码：233 / 236

页数：4

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