SANTOLINOLIDE B[(2R,3S,4S)-4-HYDROXY-2,5-DIMETHYL-3-VINYL-5-HEXENOIC ACID LACTONE] - NEW IRREGULAR MONOTERPENE FROM ARTEMISIA-TRIDENTATA-TRIDENTATA

The neutral pentane extract of the leaves arid flower heads of big sage (Artemisia tridentata tridentata) contains a new non-head-to-tail monoterpene lactone, santolinolide B (12). The steam distillate from the plant material contains a mixture of santolinolides A (11), B (12), B' (14), and C (13). The absolute stereochemical structures of these diastereomers have been established. © 1979, American Chemical Society. All rights reserved.