DIAGNOSIS OF ALCAPTONURIA - RAPID ANALYSIS OF HOMOGENTISIC ACID BY HPLC

被引：35

作者：

BORY, C ^{[1
]}

BOULIEU, R ^{[1
]}

CHANTIN, C ^{[1
]}

MATHIEU, M ^{[1
]}

机构：

[1] FAC PHAM LYON,PHARM CLIN LAB,LYONS,FRANCE

来源：

CLINICA CHIMICA ACTA | 1990年 / 189卷 / 01期

关键词：

Alcaptonuria; Homogentisic acid; HPLC;

D O I：

10.1016/0009-8981(90)90228-K

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The clinical and biochemical features of five cases of alcaptonuria were reported. The concentration of homogentisic acid was determined in urine and also in plasma using a rapid, sensitive and specific HPLC method. In all five cases, the concentrations of homogentisic acid were elevated in urine rising up to 46.5 mmol 24 h. In plasma, homogentisic acid levels ranged from 33 to 38 μmol/l. In healthy individuals, homogentisic acid was not detectable in plasma and urine. The method described represents a very useful and suitable analytical tool for the diagnosis of alcaptonuria. © 1990.

引用

页码：7 / 12

页数：6

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