HYPOPROLACTINEMIC EFFECT OF CALCITONIN GENE-RELATED PEPTIDE IN THE RAT

被引：8

作者：

ELIE, C ^{[1
]}

MOUKHTAR, MS ^{[1
]}

MILHAUD, G ^{[1
]}

CRESSENT, M ^{[1
]}

机构：

[1] UNIV PARIS 06,INSERM,U113,27 RUE CHALIGNY,F-75571 PARIS 12,FRANCE

来源：

NEUROPEPTIDES | 1990年 / 16卷 / 02期

关键词：

D O I：

10.1016/0143-4179(90)90120-N

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of calcitonin gene-related peptide (CGRP) on prolactin (PRL) secretion was studied in female rats. Prepubertal female rats were submitted to the stressful stimuli of injection, blood puncture and thermal stress. Lactating rats were exposed to suckling stimulus. The effects of CGRP on PRL release were compared to those of calcitonin (CT). CGRP i.p. or s.c. prevents the increase in circulating PRL induced by stress. This effect was observed two hrs and even 24hrs after CGRP administration. It was elicited at all doses tested, 2.5, 1.25 and 0.6 μg per animal. The time course of the actions of CGRP and CT are different. It is proposed that CGRP and CT act on different receptors. © 1990.

引用

页码：109 / 113

页数：5

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