ONLINE ANALYSIS OF PENICILLIN BLOOD-LEVELS IN THE LIVE RAT BY COMBINED MICRODIALYSIS FAST-ATOM BOMBARDMENT MASS-SPECTROMETRY

被引：49

作者：

CAPRIOLI, RM ^{[1
]}

LIN, SN ^{[1
]}

机构：

[1] UNIV TEXAS,SCH MED,DEPT BIOCHEM & MOLEC BIOL,HOUSTON,TX 77030

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 01期

关键词：

drug measurement in vivo; on-line analysis;

D O I：

10.1073/pnas.87.1.240

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The combination of microdialysis and fast-atom bombardment mass spectrometry has been used to follow the pharmacokinetics of penicillin G directly in the blood-stream of a live rat. After the intramuscular injection of the antibiotic, the blood dialysate was allowed to flow into the mass spectrometre via the continuous-flow/fast-atom bombardment interface. Tandem mass spectrometry provided the means for isolating and recording the ion fragments produced from the drug as the dialysate was exposed to the ionization process. The pharmacokinetic results obtained are compared with those previously reported in the literature, and this on-line method is discussed in terms of its particular advantages.

引用

页码：240 / 243

页数：4

共 10 条

[1] FAST ATOM BOMBARDMENT OF SOLIDS (FAB) - A NEW ION-SOURCE FOR MASS-SPECTROMETRY
BARBER, M
BORDOLI, RS
SEDGWICK, RD
TYLER, AN
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1981, (07) : 325 - 327
[2] ANALYSIS OF BIOCHEMICAL REACTIONS WITH MOLECULAR SPECIFICITY USING FAST ATOM BOMBARDMENT MASS-SPECTROMETRY
CAPRIOLI, RM
[J]. BIOCHEMISTRY, 1988, 27 (02) : 513 - 521
[3] HIGH-SENSITIVITY MASS-SPECTROMETRIC DETERMINATION OF PEPTIDES - DIRECT ANALYSIS OF AQUEOUS-SOLUTIONS
CAPRIOLI, RM
FAN, T
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1986, 141 (03) : 1058 - 1065
[4] CONTINUOUS-FLOW SAMPLE PROBE FOR FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY
CAPRIOLI, RM
FAN, T
COTTRELL, JS
[J]. ANALYTICAL CHEMISTRY, 1986, 58 (14) : 2949 - 2954
[5] GOODMAN LS, 1975, PHARMACOL BASIS THER, P1130
[6] MCLAFFERTY FW, 1983, TANDEM MASS SPECTROM
[7] PEDERSENBJERGAARD K, 1949, ACTA PHARMACOL TOX, V5, P13
[8] PHARMACOLOGY OF PENICILLIN
RAKE, G
RICHARDSON, AP
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1946, 48 (02) : 143 - 174
[9] The absorption, excretion, and distribution of penicillin
Rammelkamp, CH
Keefer, CS
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1943, 22 (03) : 425 - 437
[10] FAST ATOM BOMBARDMENT MASS-SPECTROMETRY - A POWERFUL TECHNIQUE FOR THE STUDY OF POLAR-MOLECULES
WILLIAMS, DH
BRADLEY, C
BOJESEN, G
SANTIKARN, S
TAYLOR, LCE
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1981, 103 (19) : 5700 - 5704

← 1 →