CLONIDINE ENHANCES DELAYED MATCHING-TO-SAMPLE PERFORMANCE BY YOUNG AND AGED MONKEYS

被引：61

作者：

JACKSON, WJ

BUCCAFUSCO, JJ

机构：

[1] VET ADM MED CTR,AUGUSTA,GA 30912

[2] MED COLL GEORGIA,DEPT PHARMACOL & TOXICOL,AUGUSTA,GA 30912

[3] MED COLL GEORGIA,DEPT PSYCHIAT,AUGUSTA,GA 30912

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1991年 / 39卷 / 01期

关键词：

AGING; BEHAVIOR; CATECHOLAMINES; CLONIDINE; DELAYED MATCHING-TO-SAMPLE; DELAYED RESPONSE; MEMORY; MONKEY; NONHUMAN PRIMATE; NORADRENERGIC DRUGS;

D O I：

10.1016/0091-3057(91)90400-V

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Clonidine, an alpha-2 noradrenergic agonist, has been shown to alter cognitive performance in humans and animals. Included among the evidence are studies which differ in their conclusions regarding the question of whether clonidine administration improves delayed response (DR) performance by nonhuman primates. The present results indicated that clonidine administration to both young and aged monkeys results in a modest performance improvement as measured by one of the commonly employed versions of DR performance - delayed matching-to-sample (DMTS). The clonidine-induced enhancement of DMTS had a duration of at least 24 h in both age groups.

引用

页码：79 / 84

页数：6

共 25 条

[1] CHANGES IN THE BRAIN CATECHOLAMINES IN PATIENTS WITH DEMENTIA OF ALZHEIMER TYPE [J].