POSTTRANSCRIPTIONAL REGULATION OF TUBULIN MESSENGER-RNA IN DEVELOPING RAT-BRAIN

被引：5

作者：

BHATTACHARYA, B ^{[1
]}

SAHA, S ^{[1
]}

SARKAR, PK ^{[1
]}

机构：

[1] INDIAN INST CHEM BIOL,DEPT CELL BIOL,4 RAJA SC,MULLICK RD,CALCUTTA 700032,W BENGAL,INDIA

来源：

MOLECULAR BRAIN RESEARCH | 1991年 / 10卷 / 04期

关键词：

TUBULIN MESSENGER RNA; TRANSCRIPTION; POSTTRANSCRIPTIONAL MODULATION;

D O I：

10.1016/0169-328X(91)90094-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The transcriptional activity of tubulin genes during synaptogenesis in developing rat brain has been examined by 'nuclear run off assay'. For both alpha and beta-tubulin genes, the relative rates of transcription were found to be high during the early phase of synaptogenesis (postnatal days 1-5) and declined 20-50% by the end of synaptogenesis (postnatal days 15-20). Comparison of the developmental alterations in the rates of transcription of both alpha and beta-tubulin mRNA with the level of polysomal tubulin mRNA shows that the age related decline (70-80%) in the level of polysomal tubulin mRNA during synaptogenesis is much too large compared to the 20-25% decline in their transcription rates suggesting that tubulin mRNA levels in developing rat brain are regulated post-transcriptionally.

引用

页码：347 / 350

页数：4

共 17 条

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