IS HIGHER-ORDER STRUCTURE CONSERVED IN EUKARYOTIC RIBOSOMAL DNA INTERGENIC SPACERS

被引：21

作者：

BALDRIDGE, GD

DALTON, MW

FALLON, AM

机构：

[1] Department of Entomology, University of Minnesota, St. Paul, Minnesota, 55108

来源：

JOURNAL OF MOLECULAR EVOLUTION | 1992年 / 35卷 / 06期

关键词：

RIBOSOMAL RNA; INTERGENIC SPACER; SECONDARY STRUCTURE; CHROMATIN ORGANIZATION; MOSQUITO;

D O I：

10.1007/BF00160212

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Computer-based structural analysis of the ribosomal DNA intergenic spacer (IGS) from the mosquito Aedes albopictus revealed a potential to form strong and extensive secondary structures throughout a 4.7-kilobase (kb) region. The predicted stability of secondary structures was particularly high within a 3.15-kb region containing 17 tandem 201 base-pair subrepeats. Similarly strong secondary structure potential was also found when IGS subrepeats were analyzed from 17 phylogenetically diverse eukaryotes, including vertebrates, invertebrates, and plants. Conservation of higher-order structure potential in the IGS region of ribosomal DNA may reflect evolutionary and functional constraints on chromatin organization, transcriptional regulation of the ribosomal RNA genes, and/or transcript processing and stability.

引用

页码：514 / 523

页数：10

共 64 条

[61] NUCLEOTIDE-SEQUENCE ANALYSIS OF THE SPACER REGIONS FLANKING THE RAT RIBOSOMAL-RNA TRANSCRIPTION UNIT AND IDENTIFICATION OF REPETITIVE ELEMENTS [J].