SEPARATION OF THE DIASTEREOMERS OF BACLOFEN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING CYCLODEXTRIN AS A MOBILE-PHASE ADDITIVE

被引：23

作者：

SHIMADA, K

MITAMURA, K

MORITA, M

HIRAKATA, K

机构：

[1] Faculty of Pharmaceutical Sciences Kanazawa University

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 15期

关键词：

D O I：

10.1080/10826079308019650

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Baclofen (4-amino-3-p-chlorophenylbutyric acid), a skeletal muscle relaxant used in the treatment of spastic disorders, is administered clinically as a racemic mixture. This paper describes the separation of the diastereomers of baclofen, which was derivatized with (+)-1-(9-fluorenyl)ethyl chloroformate, (+)-1-(1-naphthyl)ethyl isocyanate, 1-fluoro-2,4-dinitrophenyl-5-L-alanine amide or 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl isothiocyanate, by reversed-phase high-performance liquid chromatography using cyclodextrin as a mobile phase additive.

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收藏

页码：3311 / 3320

页数：10

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