THE GATA-3 GENE IS EXPRESSED DURING HUMAN KIDNEY EMBRYOGENESIS

被引:71
作者
LABASTIE, MC
CATALA, M
GREGOIRE, JM
PEAULT, B
机构
[1] COLL FRANCE,F-94736 NOGENT SUR MARNE,FRANCE
[2] HOP LA PITIE SALPETRIERE,HISTOL EMBRYOL & CYTOGENET LAB,PARIS,FRANCE
[3] HOP HENRI MONDOR,CNRS,UA 607,INSERM,U91,UNITE RECH GENET MOLEC & HEMATOL,CRETEIL,FRANCE
关键词
D O I
10.1038/ki.1995.223
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
GATA-3 is a transcription factor involved in the differentiation of T lymphocytes and additionally expressed in several chicken and mouse embryonic tissues. Using in situ hybridization, we found that the human GATA-3 gene is selectively expressed in the developing kidney. GATA-3 mRNA is first detected in the Wolffian duct from the time of its emergence in the embryonic intermediate mesoderm and further expressed in the collecting ducts of the mesonephros until its involution. In the metanephros, GATA-3 is expressed in the ureteric bud where it is constitutively transcribed, throughout development, along the branching process that gives rise to the whole collecting system of the definitive kidney. Besides the Wolffian duct and derivatives, we also report the expression of GATA-3 gene in the glomerular mesangium and adjacent endocapillary cells, in both meso- and metanephros. This early and specific expression of the GATA-3 gene suggests a role for this transcription factor in the differentiation of the human kidney.
引用
收藏
页码:1597 / 1603
页数:7
相关论文
共 34 条
  • [1] DEVELOPMENTAL PATTERNS OF PDGF B-CHAIN, PDGF-RECEPTOR, AND ALPHA-ACTIN EXPRESSION IN HUMAN GLOMERULOGENESIS
    ALPERS, CE
    SEIFERT, RA
    HUDKINS, KL
    JOHNSON, RJ
    BOWENPOPE, DF
    [J]. KIDNEY INTERNATIONAL, 1992, 42 (02) : 390 - 399
  • [2] PDGF-RECEPTOR LOCALIZES TO MESANGIAL, PARIETAL EPITHELIAL, AND INTERSTITIAL-CELLS IN HUMAN AND PRIMATE KIDNEYS
    ALPERS, CE
    SEIFERT, RA
    HUDKINS, KL
    JOHNSON, RJ
    BOWENPOPE, DF
    [J]. KIDNEY INTERNATIONAL, 1993, 43 (02) : 286 - 294
  • [3] TOWARDS A GENETIC-BASIS FOR KIDNEY DEVELOPMENT
    BARD, JBL
    MCCONNELL, JE
    DAVIES, JA
    [J]. MECHANISMS OF DEVELOPMENT, 1994, 48 (01) : 3 - 11
  • [4] The development of the mouse kidney - embryogenesis writ small
    Bard, Jonathan B. L.
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 1992, 2 (04) : 589 - 595
  • [5] BISHOPCALAME S, 1966, ARCH ANAT MICROSC MO, V55, P215
  • [6] BLOOM W, 1968, TXB HISTOLOGY, P652
  • [7] Gabe M., 1968, TECHNIQUES HISTOLOGI, V6th ed.
  • [8] GEORGE KM, 1994, DEVELOPMENT, V120, P2673
  • [9] LOCALIZATION OF TRANSCRIPTION FACTOR GATA-4 TO REGIONS OF THE MOUSE EMBRYO INVOLVED IN CARDIAC DEVELOPMENT
    HEIKINHEIMO, M
    SCANDRETT, JM
    WILSON, DB
    [J]. DEVELOPMENTAL BIOLOGY, 1994, 164 (02) : 361 - 373
  • [10] HUMAN GATA-3 - A LINEAGE-RESTRICTED TRANSCRIPTION FACTOR THAT REGULATES THE EXPRESSION OF THE T-CELL RECEPTOR ALPHA-GENE
    HO, IC
    VORHEES, P
    MARIN, N
    OAKLEY, BK
    TSAI, SF
    ORKIN, SH
    LEIDEN, JM
    [J]. EMBO JOURNAL, 1991, 10 (05) : 1187 - 1192