SYNTHESIS OF NEOEUDISTOMIN ANALOGS - AS POTENTIAL FILARICIDES

被引：3

作者：

AGARWAL, A

AGARWAL, SK

SINGH, SN

FATMA, N

CHATTERJEE, RK

机构：

[1] CENT DRUG RES INST,DIV MED CHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA

[2] CENT DRUG RES INST,DIV PARASITOL,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 14期

关键词：

D O I：

10.1016/0960-894X(95)00247-Q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Utilizing Pictet-spengler cyclisation, derivatives of neoeudistomin, 1-(furan-2-yl/thien-2-/3-yl/pyrrol-2-yl)-9H-pyrido[3,4-b]indoles have been synthesized. These compounds exhibited promising filaricidal activity, in vivo against Litomosoides carinii and Acanthocheilonema viteae in rodents.

引用

页码：1545 / 1548

页数：4

共 8 条

[1]

AGARWAL A, 1993, INDIAN J CHEM B, V32, P453

[2]

AGARWAL A, 1994, Z NATURFORSCH C, V49, P526

[3]

KANAMORI H, 1980, CHEM PHARM BULL, V28, P3143

[4] EUDISTOMINS C, E, K, AND L, POTENT ANTIVIRAL COMPOUNDS CONTAINING A NOVEL OXATHIAZEPINE RING FROM THE CARIBBEAN TUNICATE EUDISTOMA-OLIVACEUM [J].