THYMIDYLATE SYNTHETASE INHIBITORS - SYNTHESIS OF N-SUBSTITUTED 5-AMINOMETHYL-2'-DEOXYURIDINE 5'-PHOSPHATES

被引：11

作者：

EDELMAN, MS ^{[1
]}

BARFKNECHT, RL ^{[1
]}

HUETROSE, R ^{[1
]}

BOGUSLAWSKI, S ^{[1
]}

MERTES, MP ^{[1
]}

机构：

[1] UNIV KANSAS,SCH PHARM,DEPT MED CHEM,LAWRENCE,KS 66045

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1977年 / 20卷 / 05期

关键词：

D O I：

10.1021/jm00215a010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：669 / 673

页数：5

共 9 条

[1]

Baker BR, 1967, DESIGN ACTIVE SITE D

[2] 5-IODOACETAMIDOMETHYL-2'-DEOXYURIDINE 5'-PHOSPHATE - SELECTIVE INHIBITOR OF MAMMALIAN THYMIDYLATE SYNTHETASES [J].

BARFKNECHT, RL ;

HUETROSE, RA ;

KAMPF, A ;

MERTES, MP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1976, 98 (16) :5041-5043

[3] REPORT ON NUCLEOSIDES .5. DEOXYRIBONUCLEIC ACID UNIT 5-HYDROXYMETHYL-2-DEOXY URIDINE AND ITS ALPHA-ANOMERS [J].

BROSSMER, R ;

ROHM, E .

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1967, 348 (11) :1431-&

[4]

FRIEDKIN M, 1973, ADV ENZYMOL RAMB, V38, P235

[5] SYNTHETIC INHIBITORS OF ESCHERICHIA-COLI, CALF THYMUS, AND EHRLICH ASCITES TUMOR THYMIDYLATE SYNTHETASE [J].

KAMPF, A ;

BARFKNECHT, RL ;

SHAFFER, PJ ;

OSAKI, S ;

MERTES, MP .

JOURNAL OF MEDICINAL CHEMISTRY, 1976, 19 (07) :903-908

[6]

SEGEL IH, 1975, ENZYME KINETICS, P136

[7] FACILE SYNTHESIS OF 5'-NUCLEOTIDES BY SELECTIVE PHOSPHORYLATION OF A PRIMARY HYDROXYL GROUP OF NUCLEOSIDES WITH PHOSPHORYL CHLORIDE [J].

SOWA, T ;

OUCHI, S .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1975, 48 (07) :2084-2090

[8] CHEMICAL MODEL FOR THYMIDYLATE SYNTHETASE CATALYSIS [J].

WILSON, RS ;

MERTES, MP .

BIOCHEMISTRY, 1973, 12 (15) :2879-2886

[9] STUDIES OF PHOSPHORYLATION .3. SELECTIVE PHOSPHORYLATION OF UNPROTECTED NUCLEOSIDES [J].

YOSHIKAWA, M ;

KATO, T ;

TAKENISHI, T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1969, 42 (12) :3505-+

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