EPIDERMAL GROWTH-FACTOR BINDING IN RAT UTERUS DURING THE PERI-IMPLANTATION PERIOD

被引：29

作者：

CHAKRABORTY, C

TAWFIK, OW

DEY, SK

机构：

[1] UNIV KANSAS, MED CTR, DEPT GYNECOL & OBSTET, KANSAS CITY, KS 66103 USA

[2] UNIV KANSAS, MED CTR, DEPT PHYSIOL, KANSAS CITY, KS 66103 USA

[3] UNIV KANSAS, MED CTR, RL SMITH RES CTR, KANSAS CITY, KS 66103 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1988年 / 153卷 / 02期

关键词：

D O I：

10.1016/S0006-291X(88)81132-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The profile of epidermal growth factor (EGF) binding to uterine membranes of rats on Day 1 through Day 7 of pregnancy was studied. The binding was lowest on Day 1 and increased gradually through the pre- and postimplantation periods. Binding affinity of the Day 7 uterine membranes was considerably higher than that of the Day 1. Apparent affinity constants (Ka) of Day 1 and Day 7 membranes were 0.29 .times. 10-8 M and 1.03 .times. 10-8 M respectively. To our knowledge, this is the first report of the modulation of EGF binding to uterine membranes by progesterone-estrogen interaction during early pregnancy.

引用

页码：564 / 569

页数：6

共 24 条

[1] BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[2] MITOGENIC ACTION OF ESTRADIOL-17BETA ON HUMAN MYOMETRIAL AND ENDOMETRIAL CELLS IN LONG-TERM TISSUE-CULTURES
CHEN, L
LINDNER, HR
LANCET, M
[J]. JOURNAL OF ENDOCRINOLOGY, 1973, 59 (01) : 87 - +
[3] DIAUGUSTINE RP, 1985, 67TH ANN M END SOC B, P269
[4] PATTERNS OF CELL DIVISION IN MOUSE UTERUS DURING EARLY PREGNANCY
FINN, CA
MARTIN, L
[J]. JOURNAL OF ENDOCRINOLOGY, 1967, 39 (04) : 593 - &
[5] REGULATION OF CELL-CYCLE BY DIETHYLSTILBESTROL AND PROGESTERONE IN CULTURED ENDOMETRIAL CELLS
GERSCHENSON, LE
CONNER, E
MURAI, JT
[J]. ENDOCRINOLOGY, 1977, 100 (05) : 1468 - 1471
[6] GINNAOPOLOUS G, 1973, J BIOL CHEM, V248, P1004
[7] EXPRESSION OF RAT TRANSFORMING GROWTH-FACTOR ALPHA-MESSENGER RNA DURING DEVELOPMENT OCCURS PREDOMINANTLY IN THE MATERNAL DECIDUA
HAN, VKM
HUNTER, ES
PRATT, RM
ZENDEGUI, JG
LEE, DC
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1987, 7 (07) : 2335 - 2343
[8] GROWTH OF NORMAL MOUSE VAGINAL EPITHELIAL-CELLS IN AND ON COLLAGEN GELS
IGUCHI, T
UCHIMA, FDA
OSTRANDER, PL
BERN, HA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (12): : 3743 - 3747
[9] IKEDA T, 1984, J BIOL CHEM, V259, P4049
[10] MARQUARDT H, 1983, P NATL ACAD SCI-BIOL, V80, P4684

← 1 2 3 →