BIOSYNTHESIS OF THE TERPENOIDIC POLYKETIDE FUSALANIPYRONE

被引：9

作者：

ABRAHAM, WR ^{[1
]}

KNOCH, I ^{[1
]}

WITTE, L ^{[1
]}

机构：

[1] TECH UNIV BRAUNSCHWEIG,INST PHARMAZEUT BIOL,W-3300 BRAUNSCHWEIG,GERMANY

来源：

PHYTOCHEMISTRY | 1990年 / 29卷 / 09期

关键词：

Deuteromycetes; fusalanipyrone; Fusarium solani; methionine-d[!sub]3[!/sub]; Moniliales; monoterpene; polyketide;

D O I：

10.1016/0031-9422(90)87095-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The metabolite, fusalanipyrone, produced by Fusarium solani DSM 62416 follows the isoprene rule, so it was termed a monoterpene. However, feeding experiments with methionine-methyl-d3 showed the incorporation of deuterium into the molecule so the biosynthesis via mevalonic acid can be excluded and a polyketide pathway via a tetraketide with two subsequent methylations was established. This biosynthesis is the first example of a polyketide pathway to a formal monoterpene. © 1990.

引用

页码：2877 / 2878

页数：2