SELENOPROTEIN SYNTHESIS - AN EXPANSION OF THE GENETIC-CODE

被引：284

作者：

BOCK, A

FORCHHAMMER, K

HEIDER, J

BARON, C

机构：

[1] D-8000 München 19

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 12期

关键词：

D O I：

10.1016/0968-0004(91)90180-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of enzymes the unusual amino acid selenocysteine as part of their active site because of its high chemical reactivity. Selenocysteine is incorporated into these proteins co-translationally: biosynthesis occurs on a specific tRNA and insertion into a growing polypeptide is directed by a UGA codon in the mRNA. In E. coli, this requires a specific translation factor. Selenocysteine thus represents a unique expansion of the genetic code.

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页码：463 / 467

页数：5

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