ISOENZYME STUDIES IN HUMAN-LEUKEMIA .1. ACID-PHOSPHATASE

被引：18

作者：

GAEDICKE, G

ARNDT, R

KABISCH, H

LANDBECK, G

机构：

[1] UNIV HAMBURG,KINDERKLIN,TUMORZENTRUM HAMBURG,BLUTGERINNUNGSFORSCH & ONKOL ABT,D-2000 HAMBURG 13,FED REP GER

[2] UNIV HAMBURG,MED KLIN 1,KLIN IMMUNOL ABT,D-2000 HAMBURG 13,FED REP GER

来源：

LEUKEMIA RESEARCH | 1979年 / 3卷 / 06期

关键词：

Acid phosphatase; childhood acute leukemia; common ALL subtyping; cytochemistry to ALL; isoenzymes;

D O I：

10.1016/0145-2126(79)90038-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acid phosphatase (AcP) isoenzymes were investigated in acute lymphocytic leukemia (ALL), malignant Non-Hodgkin-lymphoma (NHL) and acute myelocytic leukemia (AML) by analytical isoelectric focusing in polyacrylamide gels (IEF). By this technique 5 groups of at least 8 isoenzymes were observed. A new subgroup of childhood common ALL (C-ALL) could be defined, lacking acid phosphatase activity by cytochemistry. However, IEF demonstrated the presence of the main isoenzyme band and the cells reacted positively with C-ALL antiserum. AcP isoenzymes of myelocytic and lymphocytic leukemic cells showed similar patterns in IEF. No leukemia specific isoenzyme could be demonstrated. The results indicate that childhood C-ALL cells may represent different differentiation stages. © 1980.

引用

页码：417 / 423

页数：7

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