IDENTIFICATION OF HUMAN IMMUNODEFICIENCY VIRUS-1 RNA AND DNA IN THE HEART OF A CHILD WITH CARDIOVASCULAR-ABNORMALITIES AND CONGENITAL ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME

被引：60

作者：

LIPSHULTZ, SE

FOX, CH

PEREZATAYDE, AR

SANDERS, SP

COLAN, SD

MCINTOSH, K

WINTER, HS

机构：

[1] CHILDRENS HOSP MED CTR, DEPT CARDIOL, DIV INFECT DIS, BOSTON, MA 02115 USA

[2] CHILDRENS HOSP MED CTR, DEPT PATHOL, DIV GASTROENTEROL & NUTR, BOSTON, MA 02115 USA

[3] HARVARD UNIV, SCH MED, DEPT PATHOL, BOSTON, MA 02115 USA

[4] NIAID, IMMUNOREGULAT LAB, BETHESDA, MD 20205 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1990年 / 66卷 / 02期

关键词：

D O I：

10.1016/0002-9149(90)90603-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Abnormalities of the heart are common in infants and children congenitally infected with the human immunodeficiency virus-1 (HIV-1). Enhanced left ventricular performance, abnormal contractility1 and increased heart mass2 are the most common of these manifestations. The etiology of these abnormalities is obscure because there is no obvious histologic or ultrastructural explanation for their presence.1 HIV-1 has been detected by Southern blot and cultivated from homogenized myocardium,3,4 but these techniques are incapable of determining the precise location of viral expression or proviral deoxyribonucleic acid (DNA) within the tissue. Using molecular techniques, we have undertaken a detailed study of 1 patient to establish the presence of HIV in myocardium and the distribution of cells producing viral ribonucleic acid (RNA) in the heart muscle. © 1990.

引用

页码：246 / 250

页数：5

共 7 条

[1] CONGESTIVE CARDIOMYOPATHY AND ILLNESS RELATED TO THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME (AIDS) ASSOCIATED WITH ISOLATION OF RETROVIRUS FROM MYOCARDIUM [J].