ESR SPIN TRAPPING AND NMR-SPECTROSCOPY OF THE SAME HEART SHOWS CORRELATION BETWEEN ENERGY DEPRESSION AND RADICAL FORMATION DURING POSTISCHEMIC REPERFUSION

被引：20

作者：

BLASIG, IE ^{[1
]}

STEINSCHNEIDER, AY ^{[1
]}

LAKOMKIN, VL ^{[1
]}

LEDENEV, AN ^{[1
]}

KORCHAZHKINA, OV ^{[1
]}

RUUGE, EK ^{[1
]}

机构：

[1] ACAD MED SCI USSR,CARDIOL RES CTR,MOSCOW 121552,USSR

来源：

FEBS LETTERS | 1990年 / 267卷 / 01期

关键词：

ESR spin trapping; High-energy phosphate; NMR; Oxy-radical; Postischemic reperfusion;

D O I：

10.1016/0014-5793(90)80280-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The relevance of radical formation in disturbances of energy metabolism in the postischemic heart is not clear. This study provides the first evidence of a significant correlation between the amount of oxy-radicals trapped in the effluent of isolated hearts upon reperfusion and the decreased myocardial content of phosphocreatine and ATP. This suggests that the loss of high-energy compounds might contribute to oxy-radical production during reperfusion. The application of ESR spin trapping and of NMR technique to the same heart is a new approach to investigate the pathobiochemical relevance of free radicals for the heart muscle. © 1990.

引用

页码：29 / 32

页数：4

共 19 条

[1] IDENTIFICATION OF FREE-RADICALS IN MYOCARDIAL-ISCHEMIA REPERFUSION BY SPIN TRAPPING WITH NITRONE DMPO [J].