DISSECTION OF THE BIFUNCTIONAL ARGRII PROTEIN INVOLVED IN THE REGULATION OF ARGININE ANABOLIC AND CATABOLIC PATHWAYS

被引:33
作者
QIU, HF
DUBOIS, E
MESSENGUY, F
机构
[1] CTR ENSEIGNEMENT & RECH IND ALIMENTAIRES & CHIM,INST RECH,1 AVE E GRYSON,B-1070 BRUSSELS,BELGIUM
[2] UNIV LIBRE BRUXELLES,MICROBIOL LAB,B-1070 BRUSSELS,BELGIUM
关键词
D O I
10.1128/MCB.11.4.2169
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
ARGRII is a regulatory protein which regulates the arginine anabolic and catabolic pathways in combination with ARGRI and ARGRIII. We have investigated, by deletion analysis and fusion to LexA protein, the different domains of ARGRII protein. In contrast to other yeast regulatory proteins, 92% of ARGRII is necessary for its anabolic repression function and 80% is necessary for its catabolic activator function. We can define three domains in this protein: a putative DNA-binding domain containing a zinc finger motif, a region more involved in the repression activity located around the RNase-like sequence, and a large activation domain.
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页码:2169 / 2179
页数:11
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