Hydrazide Pharmaceuticals as Conjugates to Polyaldehyde Dextran: Syntheses, Characterization, and Stability

被引：23

作者：

Heindel, Ned D. ^{[1
]}

Zhao, Huiru

Leiby, Jeffrey

VanDongen, Jacobus M.

Lacey, C. Jeffrey

Lima, Daniel A.

Shabsoug, Barakat

Buzby, John H.

机构：

[1] Lehigh Univ, Inst Hlth Sci, Bethlehem, PA 18015 USA

[2] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

来源：

BIOCONJUGATE CHEMISTRY | 1990年 / 1卷 / 01期

关键词：

D O I：

10.1021/bc00001a010

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The coupling of ellipticine and CI-921, two antineoplastic pharmaceuticals, to polyaldehyde dextran can be carried out under mild reaction conditions with novel acid hydrazides of the parent drugs. The resulting acyl hydrazones resist hydrolytic and enzymatic cleavage and offer a method for drug loading via dextran conjugates to monoclonal antibodies.

引用

页码：77 / 82

页数：6

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