STEROIDAL SAPONINS FROM THE RHIZOMES OF SMILAX-SIEBOLDII

被引：44

作者：

KUBO, S

MIMAKI, Y

SASHIDA, Y

NIKAIDO, T

OHMOTO, T

机构：

[1] TOKYO COLL PHARM,1432-1 HORINOUCHI,HACHIOJI,TOKYO 19203,JAPAN

[2] TOHO UNIV,FAC PHARMACEUT SCI,FUNABASHI,CHIBA 274,JAPAN

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 07期

关键词：

SMILAX-SIEBOLDII; LILIACEAE; STEROIDAL SAPONINS; SPIROSTANOL GLYCOSIDES; FUROSTANOL GLYCOSIDES; LAXOGENIN GLYCOSIDES; TIGOGENIN GLYCOSIDE; CAMP PHOSPHODIESTERASE; INHIBITORY ACTIVITY;

D O I：

10.1016/0031-9422(92)83296-B

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new steroidal saponins were isolated from the rhizomes of Smilax sieboldii. Their structures were determined by spectroscopic analysis and hydrolysis to be 3-beta-hydroxy-(25R)-5-alpha-spirostan-6-one (laxogenin) 3-O-beta-D-glucopyranosyl-(1 --> 4)-O-[alpha-L-arabinopyranosyl-(1 --> 6)]-beta-D-glucopyranoside, laxogenin 3-0-alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranoside, 3-beta,27-dihydroxy-(25S)-5-alpha-spirostan-6-one 3-0-beta-D-glucopyranosyl-(1 --> 4)-O-[alpha-L-ara-binopyranosyl-(1 --> 6)]-beta-D-glucopyranoside, 26-O-beta-D-glucopyranosyl-3-beta,22-xi,26-trihydroxy-(25R)-5-alpha-furostan-6-one 3-0-alpha-L-arabinopyranosyl-(1 --> 6)-beta-D-glucopyranoside, 26-0-beta-D-glucopyranosyl-3-beta,22-xi,26-trihydroxy-(25R)-5-alpha-furostan-6-one 3-0-beta-D-glucopyranosyl-(1 --> 4)-O-[alpha-L-arabinopyranosyl-(l --> 6)]-beta-D-glucopyranoside and (25R)-5-alpha-spirostan-3-beta-ol (tigogenin) 3-0-beta-D-gluCopyranosyl-(l --> 4)-O-[alpha-L-arabinopyranosyl-(l --> 6)]-beta-D-glucopyranoside. The inhibition of cAMP phosphodiesterase by the saponins was evaluated.

引用

页码：2445 / 2450

页数：6

共 17 条

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