MIDAZOLAM SEDATION REVERSED WITH FLUMAZENIL FOR CARDIOVERSION

被引:31
作者
FENNELLY, ME [1 ]
POWELL, H [1 ]
GALLETLY, DC [1 ]
WHITWAM, JG [1 ]
机构
[1] HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT ANAESTHET,LONDON W12 0HS,ENGLAND
关键词
ANESTHESIA; CARDIOVERSION; ANTAGONISTS; FLUMAZENIL; HYPNOTICS; BENZODIAZEPINES; MIDAZOLAM;
D O I
10.1093/bja/68.3.303
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Midazolam was used for anaesthesia in 20 patients undergoing cardioversion; 10 received flumazenil, which caused immediate rapid reversal of anaesthesia, and these patients maintained Sp02 greater than 95%, breathing air, within 5-10 min. In contrast, patients in the placebo group were still partially sedated and required oxygen therapy for up to 2 h to maintain a normal Sp02. Arterial pressure, but not heart rate, also was greater in the flumazenil group in the recovery period.
引用
收藏
页码:303 / 305
页数:3
相关论文
共 6 条
[1]  
KNAPP RB, 1970, ANESTH ANAL CURR RES, V49, P722
[2]   ELECTROPHYSIOLOGICAL AND PHARMACOLOGICAL CHARACTERIZATION OF PERIPHERAL BENZODIAZEPINE RECEPTORS IN A GUINEA-PIG HEART PREPARATION [J].
MESTRE, M ;
CARRIOT, T ;
BELIN, C ;
UZAN, A ;
RENAULT, C ;
DUBROEUCQ, MC ;
GUEREMY, C ;
LEFUR, G .
LIFE SCIENCES, 1984, 35 (09) :953-962
[3]  
MORA CT, 1989, ANESTH ANALG, V68, P473
[4]  
RIOU B, 1988, INTENS CARE MED, V14, P610
[5]  
SAVIC, 1991, LANCET, V337, P133
[6]  
THOMSON D, 1990, ACTA ANAESTHESIO S92, V34, P1