EVALUATION OF A NEW POLAR ORGANIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC MOBILE PHASE FOR CYCLODEXTRIN-BONDED CHIRAL STATIONARY PHASES

被引：147

作者：

CHANG, SC ^{[1
]}

REID, GL ^{[1
]}

CHEN, S ^{[1
]}

CHANG, CD ^{[1
]}

ARMSTRONG, DW ^{[1
]}

机构：

[1] UNIV MISSOURI,DEPT CHEM,ROLLA,MO 65401

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 1993年 / 12卷 / 04期

关键词：

D O I：

10.1016/0165-9936(93)87016-Q

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A polar-organic mobile phase system composed of acetonitrile, with small portions of hydrogen bonding modifiers, was developed for the enantiomeric separation of chiral molecules on cyclodextrin-bonded phases. This mobile phase mode allows for the separation of a wide variety of analytes which cannot be resolved in either traditional normal- or reversed-phase modes on cyclodextrin-bonded phases.

引用

收藏

页码：144 / 153

页数：10

相关论文

共 14 条

[1]

[Anonymous], 1992, Chirality, V4, P338

[2] A NEW APPROACH FOR THE DIRECT RESOLUTION OF RACEMIC BETA-ADRENERGIC BLOCKING-AGENTS BY HPLC [J].

ARMSTRONG, DW ;

CHEN, S ;

CHANG, C ;

CHANG, S .

JOURNAL OF LIQUID CHROMATOGRAPHY, 1992, 15 (03) :545-556

[3] SEPARATION OF DRUG STEREOISOMERS BY THE FORMATION OF BETA-CYCLODEXTRIN INCLUSION COMPLEXES [J].

ARMSTRONG, DW ;

WARD, TJ ;

ARMSTRONG, RD ;

BEESLEY, TE .

SCIENCE, 1986, 232 (4754) :1132-1135

[4]

ARMSTRONG DW, 1991, LC GC-MAG SEP SCI, V9, P646

[5] LIQUID-CHROMATOGRAPHIC RESOLUTION OF ENANTIOMERS CONTAINING SINGLE AROMATIC RINGS WITH BETA-CYCLODEXTRIN-BONDED PHASES [J].

ARMSTRONG, DW ;

HAN, YI ;

HAN, SM .

ANALYTICA CHIMICA ACTA, 1988, 208 (1-2) :275-281

[6] SEPARATION OF OPTICAL ISOMERS OF SCOPOLAMINE, COCAINE, HOMATROPINE, AND ATROPINE [J].

ARMSTRONG, DW ;

HAN, SM ;

HAN, YI .

ANALYTICAL BIOCHEMISTRY, 1987, 167 (02) :261-264

[7] CYCLODEXTRIN CHIRAL STATIONARY PHASES FOR LIQUID-CHROMATOGRAPHIC SEPARATIONS OF DRUG STEREOISOMERS [J].

BERTHOD, A ;

JIN, HL ;

BEESLEY, TE ;

DUNCAN, JD ;

ARMSTRONG, DW .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1990, 8 (02) :123-130

[8] STRUCTURAL FACTORS AFFECTING CHIRAL RECOGNITION AND SEPARATION ON BETA-CYCLODEXTRIN BONDED PHASES [J].

HAN, SM ;

HAN, YI ;

ARMSTRONG, DW .

JOURNAL OF CHROMATOGRAPHY, 1988, 441 (02) :376-381

[9] LIQUID-CHROMATOGRAPHIC SEPARATION OF ENANTIOMERS USING A CHIRAL BETA-CYCLODEXTRIN-BONDED STATIONARY PHASE AND CONVENTIONAL AQUEOUS ORGANIC MOBILE PHASES [J].

HINZE, WL ;

RIEHL, TE ;

ARMSTRONG, DW ;

DEMOND, W ;

ALAK, A ;

WARD, T .

ANALYTICAL CHEMISTRY, 1985, 57 (01) :237-242

[10] ENANTIOMERIC RESOLUTION AND CHIRAL RECOGNITION OF RACEMIC NICOTINE AND NICOTINE ANALOGS BY BETA-CYCLODEXTRIN COMPLEXATION - STRUCTURE-ENANTIOMERIC RESOLUTION RELATIONSHIPS IN HOST-GUEST INTERACTIONS [J].

SEEMAN, JI ;

SECOR, HV ;

ARMSTRONG, DW ;

TIMMONS, KD ;

WARD, TJ .

ANALYTICAL CHEMISTRY, 1988, 60 (19) :2120-2127